Men’s sexual health
Post-orgasmic illness syndrome: feeling unwell after ejaculation
Some men feel drained, foggy or flu-like for hours or days after ejaculating. This rare condition is called post-orgasmic illness syndrome, or POIS.
In short: POIS is a rare condition in which symptoms such as fatigue, brain fog, muscle aches, flu-like feelings, irritability and burning eyes start within minutes to hours of ejaculation and last up to a week. The cause is not fully understood; theories include an immune or allergic-type reaction and hormonal changes. Assessment by an appropriately registered medical professional is recommended.
Common symptoms
- Extreme tiredness
- Brain fog and poor concentration
- Muscle aches
- Feverish or flu-like feelings
- Irritability or low mood
- Burning or itchy eyes, blocked nose
Symptoms usually begin soon after ejaculation and may last two to seven days.
How it differs from normal tiredness
Feeling relaxed or sleepy after sex is normal. POIS symptoms are stronger, last longer and affect daily life.
Possible causes
Research is limited. Theories include:
- An immune reaction to a man’s own semen
- Changes in brain chemicals after orgasm
- Hormonal shifts
Getting assessed
POIS is diagnosed by ruling out other causes. See an appropriately registered medical professional, who may consider tests or referrals.
Coping strategies men report
- Tracking symptoms and timing
- Planning ejaculation around rest days
- Supporting sleep, hydration and stress
How we can help
Our naturopath can support overall wellbeing, sleep and stress alongside medical care, and help men talk through the impact on relationships. Read how often should a man ejaculate.
Why men choose our natural approach
Walk in or consult remotely
Walk in at Buccleuch, Sandton, with parking available, or consult by phone or video from anywhere in South Africa.
Natural and non-surgical
Herbal remedies and practical guidance, with no injections or surgery.
Faster appointments
Enquiries answered 24/7, with same-day appointments often available.
Transparent pricing
Consultations are R2,500, with any remedy costs confirmed before you commit.
Private self-check: 5 quick questions
Answer these honestly before you try anything new or book. They help you describe what is happening and get more from your first consultation.
- Do you have pain, swelling, redness or itching in the genital area?
- Have you noticed discharge, sores, a lump or blood in your urine or semen?
- Do you have a fever or feel generally unwell?
- Has this lasted more than a few days, or keep coming back?
- Is it affecting your sex life, sleep or confidence?
A yes to questions two or three, or sudden severe pain, means you should see an appropriately registered medical professional promptly. For recurring or lifestyle-related concerns, a naturopath can help with natural support alongside medical care.
What happens at your first consultation
- Walk in or book online, call +27 10 205 9855 or WhatsApp +27 81 823 1313. In Gauteng, walk in at 199 Vanessa Street, Buccleuch, Sandton, where parking is available. Outside Gauteng, choose a confidential phone or video consultation. Enquiries are answered 24/7.
- Talk privately with a naturopath about your symptoms, health history, lifestyle and goals.
- Receive a personalised natural plan, with any remedy costs confirmed upfront.
- Follow up in person or remotely so your progress is reviewed and your plan adjusted.
Your health and safety
Our naturopath uses natural remedies and lifestyle support, and always check your health history and current medicines first. If anything needs medical attention we tell you honestly and refer you to an appropriately registered medical professional. Avoid unregistered “enhancement” products sold online or at markets, as SAHPRA has warned that some contain hidden ingredients.
Seek urgent medical care for chest pain, an erection lasting more than four hours, sudden weakness or other sudden symptoms.
Consultation price
A consultation is R2,500, in person or remote, and your naturopath confirms any further costs before you go ahead. See our mens clinic prices for details.
Frequently asked questions
What is POIS?
A rare condition where men feel flu-like, foggy or exhausted for hours or days after ejaculating.
Is it normal to feel tired after ejaculating?
Mild tiredness is normal. Strong symptoms lasting days are not and should be checked.
What causes post-orgasmic illness syndrome?
The cause is unclear. Immune, hormonal and brain chemistry theories are being studied.
Who can help with POIS?
Start with an appropriately registered medical professional. Naturopathic support for sleep and stress can help alongside.
How much does a consultation cost?
A consultation is R2,500, and any remedy costs are confirmed with you before you go ahead.
Book your consultation today
Walk in at our Sandton practice any time, day or night, or book ahead. Outside Gauteng? Book a remote consultation.
References and further reading
Reviewed by George Mulaudzi, Naturopath. This page is general information and does not replace a personal consultation. If you have chest pain, sudden symptoms or a medical emergency, seek urgent medical care.
